Im assuming as the levels drop theyll wean me off. My dr never mentioned anything regarding epigenetic issues. For women 35-40 years old, there was no statistical difference (8.2% for PGT-A vs 11.0% for untested). PGS testing (aka PGT-A) is a technique to help choose the best embryo for an embryo transfer. To perform the biopsy, an embryologist removes 2-10 cells from the precursor placenta cells of the blastocyst embryo, called the trophectoderm. Trying naturally, assisted, etc. I did not do an ERA although I know a lot of people who have and have gathered helpful info from it. Thought this was tested out, but apparently that can't be detected by the PGT test. The psychologist who ran the group, who also happened to be an RE at my fertility clinic, explained that sometimes you have a seemingly perfect embryo, perfect uterine lining, and the FET just fails. Autoimmune Testing? My previous cycle where I started the prep medications (minivelle and ganirelix) was shorter (23 days) than my typical cycle (25-28) days. I actually didnt do acupuncture the second cycle, but I was in great shape. No clinic ended up quoting more than 60-70% . Does PGT-A reduce the chances of miscarriage? I miscarried a genetically normal baby girl at 8.5 weeks and they tested me for autoimmune disorders so that could be something to check for as well. Ive seen conflicting studies with some (irani 2017) saying poor quality euploid has just 25% LBR but some more recent studies (2021) that suggest that morphology matters more under 30 (which Im not Im 42 but was 37/8 at retrieval). Dear T3BK, thank you so much for your reply! Hi.all0130could you tell me what kind of endometrial scratch biospy you did?hi.T3bk.you did endometrial scratch biospy too?which one you did?era.yale eft.or something else? (2014)found no difference inongoing pregnancieswith Day 5 or 6 euploids (about 50%). Last year I got pregnant from an IUI and miscarried at 8 weeks. Design: Case-control study. Please select a reason for escalating this post to the WTE moderators: Connect with our community members by starting a discussion. Im sure that data exists especially since thats how things used to be done back in the day. You can check out my summary of the study here.. Of the 414 blastocysts transferred: 312 were euploid, 73.1% had a clinical pregnancy and 7.2% miscarried; 102 were aneuploid, 23.5% had a clinical pregnancy and . With both transfers I did estrogen tablets, progesterone in oil shots, blood thinner shots and low dose aspirin. I plan on asking my RE for a Recurrent loss panel to be done and autoimmune testing (NK cells etc)and a different protocol. Pregnancy rates will be higher because not everyone will have a live birth (some miscarry). Good luck to you on this journey and I hope round 2 is successful for you!! That sounds a lot like my dr. Its basically an assembly line in there. So the next step is transfer and my clinic is telling me to go for era in order to increase my chances. Trying to be strong and not make the holidays about my loss for the sake of my family, not sharing the news either until after. For the autoimmune stuff above I was tested by Alexander Kofinas. These stats are based off many people, so your results may not exactly hit the average. Does it still matter? But I dont think we can compare those two sets of numbers to really tell if PGS is increasing our success rates per age group. I was more relaxed overall at the second transfer, and maybe that helped. I honestly wish I had but thats all hindsight now knowing what I knew. We have some sort of make factor at play but no other known fertility issues. However, another doctor (2nd opinion) claimed that Receptiva would only be conducted for implantation failure and for those who had never seen positive pregnancy tests. my first 2 cycles were artificial but my last 2 were natural and unfortunately no luck :( Hopefully we can get somewhere with the ERA. According to the geneticist, there is as much chance it could be completely normal as the chance that it is abnormal. Hi, i didnt have chemicals, I had bfn for my first two transfers. (2018)found a reduction in clinical pregnancy when embryos were thawed, biopsied and re-frozen (the odds were about half). Hello. thanks so much! may be contradicted by other studies. Weve discussed euploid embryos, mosaic embryos, so what about aneuploid embryos? I encourage to keep pushing forward. Again, Im sorry if thats not helpful especially since your RE didnt think it was necessary for you but that was just my experience. Will be put on lovenox this round as well. Best of luck! As that was the only PGS normal embryo we had, I ended up having to do another egg retrieval. The ERA was about $800 and it took about 2 weeks to get the results. Thanks! Im glad you took time for your mental health. A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. Generally, Day 5 embryos perform better than Day 7 embryos. Reminder: I have an integrated glossary in the text (terms are underlined with a dotted black line, and when you tap on it a window will pop up with the definition). Wishing you lots of luck. I know that every cycle + embryo is different, but it's so hard to not compare cycles. 2 - IUIs both chemical My RE felt that having one good embryo was not a guarantee, so 4 rounds of retrievals it took before we had a few to work with. I suspected that my Hashimotos had something to do with the chemicals so we figured we will do IVF#4 and PGS test the embryos. Youre right! Reply Share React AMB425 Sep 2, 2016 11:01 AM thank you for sharing your success story! Thanks for sharing! MENTS THROUGHOUT MENTS You cant compare the per retrieval and per transfer stats against each other directly. Group Leaders arent expected to spend any additional time in the community, and are not held to a set schedule. This is important because miscarriage rates with advancing female age. Your experience is so inspiring, thank you for sharing . Mosaics are often transferred after euploid embryos have been exhausted, although there is evidence that low level mosaic transfers are comparable to euploid transfers (see here for a review). For your second question, Ill be doing an Embryo News this week that explains a study that compares non-PGS vs PGS tested embryos. We are absolutely crushed. If you want to read more about about success rates for untested embryos, go to my embryo grading and success rates post. Well start with euploids, then mosaics, and end with fully aneuploid embryos. I an 33 and my husband is 37. Note that once you confirm, this action cannot be undone. We have one (and only one) 4bb PGS normal embryo. Im willing to try anything :) thanks for sharing! This was our first trial. Chemical pregnancy facts. Chemical pregnancies occur so early that many people who miscarry don't realize it. My doctor really only wants me to transfer one embryo, my husband and I want to do 2. I was told by my doctor that when it is a PGS embryo that is miscarried, it is a 50% chance it was something else with the embryo (structural issues with the organs or placenta) and a 50% chance it was something about the moms body. Thinking of you , Thank you Yes, its A LOT and its weighing heavy on me since last week (when I got the call from my RE). I've read that in a non-IVF pregnancy, the rate of miscarriage is about 21.3% between weeks 5 and 6. Existing data show that the live birth rate is between 60-80% when a single frozen embryo is transferred in a second cycle. We put back a normal PGS tested embryo. Its so heartbreaking but Im trying to find some hope so I can move forward. We Tested the tissue and it was normal (??). Can I ask why they didn't test them on Day 5? Did your doctor have your SO go through the rounds of antibiotics as well? Oops, meant to say Im 17 weeks pregnant from my last FET! Advancing age of the female partner increases the chance that the embryo will be abnormal. (2017)found that Day 5 euploids had a higherongoing pregnancyrate vs Day 6 euploids (51.9% vs 32.7%). I would like to use the delestrogen shots next time instead of the patches and pills which seem to do nothing for me. An embryo with more or fewer than 23 chromosome pairs may be at increased risk of miscarriage or certain genetic disorders. I have however done Intralipid Infusions and taken Neupogen beginning a week before transfer for Autoimmune protocol (although Ive never actually been tested for Autoimmune disorder). PGS enhances the success of IVF but not in all cases; the success rates vary by age. Alternatively you can check out my websites tag for mosaic embryos here. They found a reduction in live birth rates (50% to 39%), although this was notstatistically significant(it was from a small study). So in your case it might be different since yours are chemical pregnancies but still worth asking I think :) Also someone above mentioned the endometrial biopsy which would also probably be a good idea. In contrast to mosaic embryos that are a mix of euploid and aneuploid cells, aneuploid embryos are completely aneuploid and all the cells are abnormal. He suggested an endometrial biopsy instead. I had biopsies after a polyp removal which showed residual B cells (even after 3 rounds of antibiotics), my RE didn't think much of it. Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. I"ve not had a chance to actually talk with my RE yet, hopefully I will tomorrow after I go back for monitoring. Yes, and I believe it was due to doctor negligence. We had 30 eggs retrieval. So I tried to find information through the site because I know topics like this have been posted before, BUT when I pull the results somehow PGS results in a whole lot of pregnancy posts as pg is used as a shortcut, and I am so all set with that. PGS testing done this round 8 high quality normal embryos. My second Beta I dropped to 59. Did our first FET in October with a supposedly PGT normal embryo. Consult with your doctor before making any treatment changes. Please specify a reason for deleting this reply from the community. Are there recent numbers for this comparison? Was just curious if the percentages of a live birth increase after a positive pregnancy test. Patient(s): Cases included 38 patients who underwent frozen euploid ET as determined by aCGH, resulting in miscarriage. I might actually look into that. Note: I'm also doing a pregnancy loss blood panel to investigate clotting, and am looking into autoimmune causes as well. But I do have a friend who had 1 embryo shipped from Utah to California for an FET and it was a different clinic that handled the FET. An embryo forms and may even embed in your uterus lining (implantation), but then it stops developing. I think whats missing is the success rates for transfers of non PGS tested embryos. She says that with PGS tested embryos my rate to achieve pregnancy is 70% and a twin pregnancy is at 50%. Good luck and dont give up on hope yet! Starting in the late 1990s, doctors testing fertilized eggs classified them as normal or abnormal, then added the classification "mosaic" in 2015. My first FET with my only normal embryo was successful but ended at 7.5 weeks with a MMC The devastation was unreal. Did testing and just found out it was a triploid embryo so it had 69 chromosomes. I also know that no one can make this decision for me. I would Love and Need your opinions on this. Because all the women who didnt have embryos to transfer are now included and lower the overall success for that age group. Any advice is greatly appreciated. First, PGS improves pregnancy rates. 2014). I also did Neupogen but they still wanted to test for autoimmune disorders. Ive had two biochemical losses with day 6 4BC euploids and with 1 day 6 4BC left to try, Im wondering our odds. Create an account or log in to participate. Its such a good point and one that is often missed, I think. Congratulations again on your success!!! I had a chemical with a PGS embryo in October. Bradley et al. Are you sure you want to block this member? The FET process can take a few tries even with a PGS tested embryo. I know Im shocked this was never brought up by my doctor, after everything. It took me 3 fresh + 3 frozen but I finally did get my baby. Disclaimer: Any studies presented here may be contradicted by other studies. Would you ladies push next time for a different protocol? Thats a great suggestion, I will definitely ask my dr about doing an ERA. Women who have three chromosomally-normal embryos as a result of In Vitro Fertilization (IVF) have a 94.9% chance of achieving pregnancy, research conducted by Reproductive Medicine Associates (RMA) and presented at the annual meeting of the American Society for Reproductive Medicine (ASRM) shows. The Munne et al. I had been on birth control since I was 18 and had no idea what to expect when I came off it. You said that The per retrieval statistic helps to see the chances before PGS testing. But it almost seems like there should be another set of statistics for better putting success rates into perspective. Success is still very possible, IVF treatments are often a trial and error situation as my doctor put it once. Preimplantation genetic testing (PGT) is the process of testing embryos created during in vitro fertilization (IVF) to determine the presence of genetic abnormalities that can lead to pregnancy complications, birth defects, congenital disease and/or miscarriage. I find the live birth rates by transfer versus by retrieval data very interesting. is there another clinic in your area you can switch to? Has anyone had this happen and did any further testing determine the cause? Poor quality embryos are they worth PGS testing? All that to say, it's likely that there actually was something wrong with that embryo - but it's worthwhile to leave no stone unturned before trying again. Its not a ton of time to do and it might make the difference. Check here for the full. Low hCG levels. Best of luck on your next FET! MENTS I am also going through a chemical pregnancy this week, but with an untested embryo (so, that's very likely the reason for my loss). Aneuploids on the other hand, at least based on 1 study, seem to have a 100% miscarriage rate. And congrats on your little girl! , Ive done embryo glue every transfer but no luck unfortunately :(. Genetic testing was normal. She said that this is something that is prevalent in recurrent pregnancy loss and failed implantations. The results come back as euploid (meaning theres 46 chromosomes), aneuploid (meaning theres a number of chromosomes besides 46) or mosaic (meaning theres a mix of euploid and aneuploid cells). Thank you! Very frustrating to have an inconclusive. The good thing is she did not see any scar tissue during the biopsy, and the inflammation had completely cleared up. Second, PGS speeds up the time to pregnancy. Dear ALL0130, thank you so much for your reply and encouragement! At the time, I was at rock bottom and going to an online support group. MENTS my 3rd FET was a success end MENTS. As mentioned in the study, about 72% of mosaic miscarriages occurred between observation of the gestational sac (3-5 weeks after transfer) and fetal heart beat (6-8 weeks after transfer). in reply to 3 years ago Thank you so much! MENTS my FET following that one was successful and I am now 28 weeks pregnant END MENTS .This whole IVF journey takes so much out of you and I truly feel your pain but please keep trying. How fast embryos grow has an impact on success rates for untested embryos. Check here for the full glossary (please excuse the repeated terms!). Ill also update this blog to include that info. I may not have that exactly correct but thats how I understood it. So, all is well! This can be done! undefined will no longer be visible to you including posts, replies, and photos. I had the biopsy done twice; one to test (which I was positive for) and one to ensure it was no longer present after a round of strong antibiotics. This November I did a frozen transfer with an untested, five day embryo and Im 9 weeks now. My RE didnt change a thing between round 1 and round 2, and I didnt do anything differently. This isnt very surprising considering these embryos have no cells that are euploid in order to self-correct (read more about that here). Mosaics are embryos that have a mix of euploid and aneuploid cells. Hi! (2018)looked ateuploidembryos (aCGH/SNP) in women <35: Irani et al. Consult with your doctor before making any treatment changes. A few rounds of heavy- duty antibiotics cleared it up. Embryoman (Sean Lauber) is a former embryologist and creator of Remembryo.com. So mosaics can have a varying rates of miscarriage depending on the type of abnormality present. And demand that my lining be over 8 before I allow another transfer to occur? ALL THREE DID!!! Looking for anyone who has had recurrent chemical pregnancies and then found success. We know about the epigenetic issue from testing the sperm but its not a test that you can do on the embryos (would have to kill them), I hope you are able to figure out what is going wrong and fix it! With a PGS tested embryo this time. Ive done intralipid infusions and Neupogen each time in the case I had an autoimmune disorder or natural killer cells so I dont think that would be the issue. Do the birth success rates of pgs tested embryos include both those that get a positive pregnancy test and those that dont? PGS can increase the rate of clinical pregnancy. Your post will be hidden and deleted by moderators. (2021) in their retrospective multicenter study compared the transfer of 1000 mosaic embryos and over 5500 euploid embryos between 2015 and 2020. We decided to see an RE given our age. , thats definitely worth looking into as well! In large scale Double Blind Randomized Control Trials (the best method for medical protocol research) PGT did not increase your chances of pregnancy, except in some scenarios. However, theirsample sizewas small. Lack of common pregnancy symptoms like morning sickness or breast soreness after a positive pregnancy test. ERA testing. Wondering if anyones had a similar experience or has any advice. Next lets look at how mosaics perform in terms of miscarriage (often using euploids as a control so for you euploid people out there, you might want to check the next section also!). I wanted to reach out and see if you know a way to find a surrogate on your own, rather than going thru an agency. Seems to work for many, many women. We transferred our only day 6/PGS tested Euploid embryo on December 10,2020. Even though I ended up with no good embryos I recommend it because I think it's good to know now and not later with a miscarriage. I have a whole page dedicated to mosaic embryos. My husbands sperm analysis was only very slightly abnormal. My clinic does allow each patient to continue with one retrieval with only 1-2 follicles, however, for cost reasons since we're doing ICSI and PGS testing I'm considering cancelling the cycle. It's my second transfer. We decided to start with IUI with clomid which resulted in another chemical pregnancy. Your clinic may have a better idea! I also tested positive for anti-thyroid antibodies. Praying you did and thank you for the advice! I had a chemical last November with a PGS normal embryo and was successful with the second FET in July. I just received news today that out of our 14 blastocysts only 4 passed pgs and 1 with no result that we are retesting. There is much better chance of IVF success with PGS testing in women who were over the age of 35. It is seriously invaluable to me. Capalbo et al. Live birth rate differences are inconsistent and therefore inconclusive. Not exactly! Your post will be hidden and deleted by moderators. However we now understand that the chromosomes are only part of the issue. Like embryo grades in the previous section, it looks like IVF with PGS success rates may vary based on how fast the embryo develops, particularly for Day 7. RPL and endomitritis biopsy isnt a new thing, and its the same procedure as an ERA (which I also highly recommend). I've experienced 3 chemical pregnancies - one naturally (7/2017), one via our 2nd IUI (9/2018), and the third this January after our FET with a PGS tested embryo. Some background on us: diagnosed with severe male factor IF 4 years ago, did one round of IVF/ICSI which resulted it a chemical pregnancy. What would they tell me and how would they impact protocol differently? But then the 3 mature eggs I had all fertilized, all made it to blast, all tested normal, and now one of them is my 15 month old daughter. However, these differences were not found in women older than 30 years. Please can you offer a perspective? Multiple losses due to chromosomal abnormality, did you do ivf? think twice before sharing personal details, foster a friendly and supportive environment, remove fake accounts, spam and misinformation, delete posts that violate our community guidelines, reviewed by our medical review board and team of experts. 144 abnormal (aneuploid/mosaic) embryos and their outcomes. Thank you Its so hard when youre paying yet your doctor doesnt think its needed. A pregnancy that doesn't even make it to the 6 week scan where they can usually see the fetus on an ultrasound. If you want to read more about rebiopsying embryos, check out my archives for embryo rebiopsy. With the second, the only change was to add low dose steroids. I did acupuncture that cycle. Terms are highlighted every 3rd time to avoid repetition. We are currently looking to use a gestational surrogate in Texas. Group Owners uphold the core values of the brand by reporting content that violates the community guidelines. Im sorry to hear of your loss! I just found out today that I've only got 2 larger follicles and 3 smaller ones that are growing but are quite behind the 2 larger ones. And Im so sorry about your first FET. I am thinking of you and truly wish you the best in January , Im sorry for a late response Ive been off the app to work on my mental health. Definitely heartbroken but trying to look forward.
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